Employment

Employment

 

 

Animal Technician

 

We are currently seeking a part-time experienced animal technician for our in vivo research projects. Duties will involve the daily care and husbandry of research animals.

 

Duties include:

  • General rodent husbandry and care for the animals used in research studies. Performs duties related to the maintenance of experimental animals such as cleaning cages, feed and water, maintaining inventory and ensuring animal identification records.
  • Performs cleaning/sanitation of animal facility and equipment.
  • Daily health monitoring (taking body weight measurements), collecting other in vivo data, dosing of animals (ip, iv, sc, in, it, ih), and collecting the organ samples (tail vein, retro-orbital, or cardiac bleeding and extracting organ tissues).
  • All work will involve the direct handling of laboratory mice with a potential work with rats and other rodents.
  • Proficient with compound dosing and collection of samples for PK/PD and efficacy studies
  • Experience with in vivo disease models involving bacteria and viruses is highly desired
  • Responsible for bio-safety and bio-security of the animals.
  • The candidate is also required to work in a barrier facility and wearing proper PPE
  • High school degree or equivalent, college degree preferred
  • Authorization to work in the US

 

Requirements:

    • AALAS certification (ALAT or higher) preferred.
    • Skill and knowledge to apply principles of animal handling in compliance with AAALAC standards.
    • Competent at entering data onto a laptop computer.
    • Availability to work variable schedule including weekends and holidays.
    • Accurate record keeping and troubleshooting skills
    • Self-motivated, flexible, and willing to meet strict time lines
    • Strong interpersonal communication skills
    • Ability to work in a fast paced, goal oriented, team-based environment

 

Ardis Pharmaceuticals, Inc. is a biopharmaceutical company focused on the development of novel, differentiated therapies for infectious diseases. Complementing the product pipeline is a disruptive platform technology to discover rare, potent human monoclonal antibodies from patients.
Our mission is to introduce much needed innovations to infectious disease treatment using an anti-infective product portfolio that includes four (4) clinical stage and two preclinical drug candidates.  Our antimicrobial product candidates are highly differentiated from conventional antibiotics in mechanisms of action, and are being developed using clinical study designs that allow for clear demonstration of superiority over standard of care antibiotics. Our scientists and leadership team have a proven track record of innovation and successful drug development of therapeutic candidates from early discovery to commercial implementation.

 

For immediate consideration, please submit your cover letter and resume to: weichn@aridispharma.com

 

 

Scientist, Cell Biology & Antibody Development

 

COMPANY :

Aridis Pharmaceuticals, Inc. is a biopharmaceutical company focused on the development of novel, differentiated therapies for infectious diseases. Complementing the product pipeline is a platform technology to discover rare, potent human monoclonal antibodies from patients. The Company’s mission is to introduce much needed innovations to infectious disease treatment using an anti-infective product portfolio that includes four (4) clinical stage and two preclinical drug candidates.  Our antimicrobial product candidates are highly differentiated from conventional antibiotics in mechanisms of action, and are being developed using clinical study designs that allow for clear demonstration of superiority over standard of care antibiotics.

 

SUMMARY OF POSITION:

Aridis Pharmaceuticals is seeking a highly innovative and creative scientist with expertise in cell biology technologies to contribute to our efforts for the discovery and characterization of monoclonal antibodies to support our internal pipeline technology programs. This role requires a core focus on the development of robust protein and antibody expression cell lines and handson experience with antigen-antibody assay development and analysis. The successful candidate will be expected to apply comprehensive cell biology techniques to perform screening and characterization assays to support antibody discovery and cell line development workflow.

 

The duties of the job include experimental design and execution, analysis and interpretation of data, and verbal/written presentation of findings to the research team and senior management. Proven ability to solve technical problems, and work both independently and across functions. The successful candidate will be both a strong lab-based individual contributor and a team player who synergizes with other scientists. The candidate will contribute to key discovery studies which will have a direct impact on the success of our therapeutic programs.

 

RESPONSIBILITIES:

  • Serve as a key contributor to the development of antibody therapeutics for infectious disease targets
  • Contribute to the development of strategies to express, purify and analyze proteins for novel targets expressed in mammalian cells and evaluate emerging technologies
  • Characterize antibodies including binding affinity and binding kinetics through Octet/Biacore, epitope binning/mapping, and functional assays
  • Generate stable/clonal genetically modified cell lines
  • Contribute to the design and implementation of antibody discovery through immunogen assay development and screening
  • Support antibody discovery workflow including performing hybridoma fusions, clone picking, single cell identification and hybridoma antibody screening
  • Analyze data, interpret results, identify problems, and develop trouble shooting plans

 

QUALIFICATIONS:

  • MS Cell Biology, Biochemistry, Immunology or related field with 2+ years industry experience, or BS with 6+ years of industry experience.
  • Experience with protein-protein interaction using a variety of methods such as ELISA, FACS, Bio-Layer Interferometry (Octet)
  • Experience with cell biology techniques including mammalian cell culture, transfection and functional cell-based assays
  • Experience with hybridoma and B cell technologies, including cell sorting, single cell identification, antigen-antibody analysis
  • Experience with small scale antibody and protein purification
  • Experience with cell line development (CLD) activities including identification of CLD related issues
  • Experience with GMP compliant/quality control procedures is a plus
    Proven scientific skills with the ability to solve technical problems, and work both independently and across functions
  • Excellent lab practice/organization and communication required
    Ability to contribute to multiple projects in a fast-paced environment

 

Aridis Pharmaceuticals is an equal opportunity employer and will consider all qualified applicants for employment.

 

For immediate consideration, please submit your cover letter and resume to: weichn@aridispharma.com

 

 

 

Scientist, Molecular Gene Editing and Engineering

 

COMPANY:

Aridis Pharmaceuticals, Inc. is a biopharmaceutical company focused on the development of novel, differentiated therapies for infectious diseases. Complementing the product pipeline is a disruptive platform technology to discover rare, potent human monoclonal antibodies from patients. The Company’s mission is to introduce much needed innovations to infectious disease treatment using an anti-infective product portfolio that includes four (4) clinical stage and two preclinical drug candidates.  Our antimicrobial product candidates are highly differentiated from conventional antibiotics in mechanisms of action, and are being developed using clinical study designs that allow for clear demonstration of superiority over standard of care antibiotics.

 

SUMMARY OF POSITION:

We are currently seeking a highly innovative and creative scientist with expertise in molecular gene editing technologies to support our internal pipeline technology programs. This role requires a core focus on the development of robust protein and antibody expression systems and handson experience with molecular gene editing. Duties will involve the development of cell line genetic engineering approaches for research discovery and cell line development and will support commercial manufacturing programs.

 

The duties of the job include experimental design and execution, analysis and interpretation of data, and verbal/written presentation of findings to the research team and senior management. Proven scientific leadership with the ability to drive innovation, lead projects and teams, solve technical problems, and work both independently and across functions. The successful candidate will be both a strong lab-based individual contributor and a team player who synergizes with other scientists. The candidate will contribute to key discovery studies which will have a direct impact on the success of our therapeutic programs.

 

RESPONSIBILITIES:

  • Genetic editing/engineering of mammalian cell lines, using various transduction methods, CRISPR engineering or other novel editing platforms.
  • Develop molecular strategies for genomic engineering by applying the latest genetic manipulation technologies for optimized efficiency and specificity scalable for manufacturing processes.
  • Design, generate, and produce DNA constructs using standard cloning techniques including ligation and assembly
  • Designing sgRNAs and repair templates to carry out editing, knock-in and knock-out of genes
  • Carrying out genome-wide (eg. SITE-seq/ GUIDE-seq/ CIRCLE-seq, followed by amplicon-seq) quantitative analysis to identify and quantify off-target effects
  • Supporting efforts to optimize CRISPR delivery methods in cell lines
    Optimizing targeting conditions customized to different gene editing applications.

 

QUALIFICATIONS:

  • Requires Ph.D. degree in cell biology, molecular biology or related field and minimum 2+ years postdoctoral experience in cell line engineering in academia or industry
  • Demonstrated expertise in cutting edge gene editing technologies, including gRNA design, donor template building, genome cleavage assays, off-target editing evaluation, genomic integration analysis.
  • Extensive experience in molecular cloning, vector construction, transfection and viral infection, and transgene expression.
  • Experience in working with cGMP compliant/quality-controlled procedures is a plus
  • Authorization to work in the United States

 

Aridis Pharmaceuticals is an equal opportunity employer and will consider all qualified applicants for employment.

 

For immediate consideration, please submit your cover letter and resume to: weichn@aridispharma.com