JOIN OUR TEAM
Are you looking for a positive and stimulating work environment? Joining Aridis Pharmaceuticals means choosing a fast growing, innovative and collaborative company committed to advancing transformative, first-in-class anti-infectives for life-threatening respiratory infections. We are always looking for passionate and talented individuals to join our dedicated team to help us achieve our mission.
Explore our open positions below:
Scientist: Therapeutic Antibodies
Aridis Pharmaceuticals, Inc. (www.aridispharma.com) is a biopharmaceutical company based in Los Gatos, CA that focuses on developing innovative immunotherapies for infectious diseases. Complementing the product pipeline is a platform technology to discover rare, potent human monoclonal antibodies from patients. Aridis’ portfolio of monoclonal antibodies (mAbs) is comprised of five candidates, three of which are in late clinical development. Our antimicrobial product candidates are highly differentiated from conventional antibiotics in mechanisms of action, and are being developed using clinical study designs that allow for clear demonstration of superiority over standard of care antibiotics.
Aridis Pharmaceuticals is currently seeking a highly motivated and results-oriented scientist to contribute to our efforts in the discovery and preclinical development of novel antiviral and antibacterial monoclonal antibodies. The successful candidate will develop and execute the program from antibody discovery to lead selection and characterization. We are looking for a self-motivated team player who thrives in a dynamic, fast-paced working environment.
- Lead efforts in discovery, selection, production and characterization of lead antibody candidates
- Express, purify and analyze novel target proteins
- Contribute to the design and implementation of the antibody discovery process
- Develop methods to functionally screen therapeutic antibodies and identify lead candidates
- Keep current on relevant scientific literature
- PhD and minimum of 2+ years of post-doctoral experience
- Background in virology and experience in virus/VLP/PsV production
- Experience with protein production in mammalian and bacterial systems including purification
- Experience with trans-membrane (TM) proteins preferred
- Experience with mammalian cell culture and associated techniques, especially FACS, preferred
- Experience with biophysical and functional protein characterization including cell-based assays involving mAbs desired
- Working knowledge of immunology is a plus
- Experience with analysis of omics data sets is a plus
- Strong analytical skills
- Good publication record
- Team player with ability to work independently
- Must be eligible to work in the US on an unrestricted basis
Aridis Pharmaceuticals is an equal opportunity employer and will consider all qualified applicants for employment.
Research Associate, Molecular Biology
Aridis Pharmaceuticals, Inc. is a biopharmaceutical company focused on the development of novel, differentiated therapies for infectious diseases. Complementing the product pipeline is a platform technology to discover rare, potent human monoclonal antibodies from patients. Complementary technologies to develop commercial production cell lines is a key goal of Aridis Pharmaceuticals. The Company’s mission is to introduce much needed innovations to infectious disease treatment using an anti-infective product portfolio that includes four (4) clinical stage and (4) preclinical drug candidates. Our antimicrobial product candidates are highly differentiated from conventional antibiotics in mechanisms of action, and are being developed to expand the current standards of care.
SUMMARY OF POSITION:
We are currently seeking a creative and detail-oriented Research Associate with experience in molecular biology to support our internal pipeline technology program within our APEXTM platform and discovery group. This role requires a core focus on the construction of new molecular plasmids, assay development supporting molecular gene editing, and generation of stable, clonal cell lines. Hands-on experience with techniques in genome engineering and virus transduction methodologies are highly desirable.
The successful candidate will be both a strong lab-based individual contributor and a team player who works well with other scientists. The candidate will contribute to key discovery studies which will have a direct impact on the success of our therapeutic programs.
- Perform molecular cloning to assemble novel plasmid DNA constructs.
- Perform standard PCR and RT-qPCR assays in mammalian cells and cell lines.
- Perform and optimize transfection and transduction for delivery of plasmids and viral vectors for stable and transient gene expression in cell lines.
- Maintain cell lines through transfection and selection for the generation of transient and stable clones.
- Perform in vivo gene editing using CRISPR-associated (Cas) proteins.
- Express recombinant proteins and characterize protein expression using standard assays (e.g., SDS-PAGE, western blot).
- Accurately document experimental protocols, perform analysis and help with interpretation of data, and report key findings to senior management and research team.
- Proficiency in working with various DNA analysis software programs such as Snapgene, Lasergene or their equivalent, and with Microsoft Office (Word, Excel, Powerpoint).
- B.S. in molecular and cellular biology, biochemistry, immunology, or a related field.
- 2 years (or more) relevant laboratory-based experience in industry or academia.
- Experience with molecular cloning, including plasmid DNA construction, transformation, and isolation, nucleic acid extraction, DNA mini- and maxi-prepping procedures and DNA sequence analysis.
- Experience in gel-based assays (DNA gels, protein gels, western blot).
- Experience in genomic DNA isolation and mRNA purification, and RT-qPCR.
- Experience in standard tissue culture techniques and maintaining cell lines.
- Experience performing independent data analysis using routine software tools.
- Demonstrated ability to execute experiments both independently and as part of a team.
- Strong communication and interpersonal skills.
- Authorization to work in the United States.
- Expertise in vector construction techniques such as PCR, Gibson assembly, Golden-Gate assembly, restriction enzyme digestion and ligation.
- Experience with viral vectors (e.g., AAV/lentiviral).
- Experience in single cell isolation and cloning and fluorescence-based cell identification using either microscopy or flow cytometry methods.
- Experience in working with cGMP compliant/quality-controlled procedures is a plus.