Quick dissolving oral thin films dosage form (e.g. Listerine^TM breath freshener strips) is seeing increased market because of delivery advantages including accurate & full dosing, small packaging size, easy handling and administration. Additionally, the film manufacturing processes are well established and cost effective. However, these processes are generally harsh, involving high heat, pressure, and organic solvents, thus are not applicable for more fragile drugs such as those which are protein-based and vaccines.

Aridis' approach is to apply its plasticized powder technology to pre-stabilize sensitive drugs so they can retain the activity through the film fabrication process. Aridis’ oral thin film delivery system, co-developed with Johns Hopkins University, uses pre-stabilized powder drugs and a pH responsive polymer system to generate storage stable thin films that can protect the drug against inactivation during transit through the gut. The result is the world's first quick-dissolving thin film delivery system incorporating enteric protection. RotavaxTM vaccine encased in this novel ora thin films were stable for more than one year at room temperature and able to withstand temperatures excursions above 45 °C.